Sugar acids and derivatives
TARGETMOL CHEMICALS INC Gypsogenin-3-O-glucuronide 5MG
Also available in 1 mL, 1 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. 1. Gypsogenin-3-O-glucuronide (Methyl gypsogenin 3-O-beta-D-glucuronopy) shows inhibitory activity toward pancreatic lipase with IC5 value of .29 mM, and the free carboxylic acid groups in position 28 within its chemical structures are required for enhancement of pancreatic lipase inhibition. Purity 99.33%
Apexbio Technology LLC 7-Methoxycoumarin-4-acetyl-P-L-G-L-β-(2,4-dinitrophenylamino)A-R amide 140430-53-1 5mg
7-Methoxycoumarin-4-acetyl-P-L-G-L-beta-24-dinitrophenylamino A-R amide (CAS 140430-53-1) is a fluorogenic peptide substrate targeting matrix metalloproteinases (MMPs) It is designed to enable the continuous measurement of MMP enzymatic activity which is achieved by monitoring substrate cleavage between Gly and Leu residues 7-Methoxycoumarin-4-acetyl-P-L-G-L-beta-24-dinitrophenylamino A-R amide exerts its utility through a fluorescence-based mechanism cleavage by MMPs separates the fluorescent reporter group from the quencher resulting in increased fluorescence signal Based on these properties 7-Methoxycoumarin-4-acetyl-P-L-G-L-beta-24-dinitrophenylamino A-R amide is employed in biochemical assays for the quantification of total or specific MMP activity in biological samples and enzyme preparations
Medchemexpress LLC N-Acetylneuraminic acid | 131-48-6 | 99.9% | 309.27 | 250 MG
N-Acetylneuraminic acid | 131-48-6 | 99.9% | 309.27 | 250 MG
Medchemexpress LLC Intestinal Alkaline Phosphatase Antibody (YA1559) | 50 UL
Intestinal Alkaline Phosphatase Antibody (YA1559) is a rabbit-derived, non-conjugated IgG monoclonal antibody that targets Intestinal Alkaline Phosphatase. This enzyme functions as an alkaline phosphatase, hydrolyzing various phosphate compounds. It is a component of the gut mucosal defense system, involved in the detoxification of lipopolysaccharide and the prevention of bacterial translocation in the gut.
- Rabbit-derived, recombinant, monoclonal antibody
- Reacts with human species
- Immunogen is a synthesized peptide derived from human intestinal alkaline phosphatase aa1-55/528
- Subcellular localization: cell membrane, lipid-anchor, GPI-anchor
- Forms a homodimer
- Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA
- For research use only
Medchemexpress LLC P53 (17-26), FITC labeled | 98.3% | 1752.98 | 10 MG
P53 (17-26), FITC labeled is a biologically active peptide intended for research use. It presents as a light yellow to orange solid with a purity of 98.31%.
- For research use only
- Molecular weight: 1752.98
- Appearance: Solid
- Color: Light yellow to orange
- Sequence: {FITC-Ahx}-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-NH2
- Soluble in DMSO (≥ 100 mg/mL)
Medchemexpress LLC D-Psicose (Standard) | 551-68-8 | MFCD00083478 | 99.9% | 180.16 | 25 MG
D-Psicose (Standard) is an analytical standard used for research and analytical applications. It is an orally active rare sugar that inhibits p38-MAPK phosphorylation and MCP-1 expression. It also inhibits the AGEs/RAGE/NF-κB pathway and protects pancreatic β-islets, improving hyperglycemia and high-fat diet-induced non-alcoholic fatty liver disease.
- Intended for research and analytical applications
- Inhibits p38-MAPK phosphorylation and MCP-1 expression
- Inhibits the AGEs/RAGE/NF-κB pathway
- Protects pancreatic β-islets
- Improves hyperglycemia
- Improves high-fat diet-induced non-alcoholic fatty liver disease
- Suitable for qualitative, quantitative and methodological research experiments in HPLC, GC and MS
- Analytical standard grade
Medchemexpress LLC AMG 333 | 1416799-28-4 | 99.8% | 453.32 | 25 MG
AMG 333 is an orally active and highly selective TRPM8 antagonist with an IC50 of 13 nM. It dose-dependently inhibits wet-dog shake behavior and blocks blood pressure elevation in rat models, making it a clinical candidate for the treatment of migraine.
- Orally active and highly selective TRPM8 antagonist
- Dose-dependently inhibits wet-dog shake behavior in the Icilin-induced wet-dog shake Sprague-Dawley rat model
- Dose-dependently blocks blood pressure elevation in the cold stimulation-induced blood pressure elevation Sprague-Dawley rat model
- A clinical candidate for the treatment of migraine
Apexbio Technology LLC N-Acetylneuraminic acid 131-48-6 100mg
N-Acetylneuraminic acid (131-48-6) is a monosaccharide located at the terminal positions of glycoproteins on mammalian cell membranes It modulates cell signaling adhesion and recognition processes by altering glycoconjugate structures N-Acetylneuraminic acid exerts its biological activity primarily through regulation of sialylation patterns on surface glycoproteins which influence tumor cell proliferation adhesion dynamics and metastatic potential Key metric values such as IC50 vary significantly depending on the biological model and assay conditions Based on these properties N-Acetylneuraminic acid holds research potential in tumor biology cardiovascular injury models lipid metabolism disorders and studies of membrane protein interactions and tumor metastasis
Medchemexpress LLC D-Glucose, O-α-D-glucopyranosyl-(1→6)-O-α-D-glucopyranosyl-(1→4)- | 33401-87-5 | 99.95% | 504.44 | 25 MG
D-Panose is an oligosaccharide composed of glucose units linked by specific glycosidic bonds. It is a PAN-type oligosaccharide and a food ingredient based on isomaltooligosaccharides (IMOs). It can be detected with high sensitivity in SALDI-MS using magnesium oxide nanoparticles as the matrix.
- Composed of glucose units.
- PAN-type oligosaccharide.
- Food ingredient based on isomaltooligosaccharides (IMOs).
- High sensitivity detection in SALDI-MS.
- For research use only.
Medchemexpress LLC Platycodin D | 58479-68-8 | 1225.32 | 25 MG
Platycodin D is a saponin isolated from *Platycodon grandiflorus*. It acts as an activator of AMPKα and possesses anti-obesity properties. The WNT/β-catenin pathway mediates its anti-adipogenic effect.
- Saponin isolated from *Platycodon grandiflorus*.
- Activator of AMPKα.
- Anti-obesity property.
- WNT/β-catenin pathway mediates its anti-adipogenic effect.
![Apexbio Technology LLC vitamin D binding protein precursor (353-363) [Homo sapiens] 10mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000096705.png-250.jpg)
Apexbio Technology LLC vitamin D binding protein precursor (353-363) [Homo sapiens] 10mg
Vitamin D binding protein precursor 353-363 is a serum glycoprotein fragment derived from Homo sapiens It is associated with vitamin D binding protein (DBP) a plasma protein that binds vitamin D metabolites and actin monomers mediating transport in the bloodstream and regulation of extracellular actin levels DBP is present on surfaces of various immune cell types including B and T lymphocytes as well as placental cytotrophoblasts Based on these pharmacological properties vitamin D binding protein precursor 353-363 holds research potential in studies of vitamin D metabolism immune regulation and cytoskeletal interactions
Medchemexpress LLC Knt-127 | 1256921-89-7 | 99.6% | 25 MG
KNT-127 is a selective, blood-brain barrier penetrant δ-opioid receptor (DOR) agonist used in neuroscience research; it preferentially activates cAMP signaling with reduced β-arrestin recruitment.
- Selective δ-opioid receptor agonist with reported Ki = 0.16 nM
- Blood-brain barrier penetrant, suitable for in vivo studies
- Biased ligand favoring cAMP signaling over β-arrestin pathways
- High reported purity (99.6%) appropriate for research applications
- Available in small pack sizes, including 25 mg
Medchemexpress LLC 4-Methylumbelliferyl 10mM | 440.61 g/mol | C28H40O4 | 10MM 1ML
4-Methylumbelliferyl oleate is a fluorogenic substrate for acid and alkaline lipases 4-Methylumbelliferyl oleate is cleaved by lipases liberating 4-Methylumbelliferyl (Ex/Em 320/450 nm)[1][2]